Ethnomedicine Against Jaundice Used by Gond Tribes of Adilabad District, Andhra Pradesh, India

The present investigation was performed in order to enumerate the medicinal plants that gond tribes uses for the treatment of jaundice in Adilabad district, Andhra Pradesh, India. The study revealed that totally 12 plants belonging to 9 families were used to cure jaundice . The plants were used either separately or in combination with some other plant parts.

Regulatory Model of Mirna-125 in Leukemia

MicroRNAs (miRNAs) are small, subtypes of RNA that are 22-25 nucleotides in length that regulate the gene expression by targeting homologous sequences in messenger RNA (mRNA). Their unusual expressions have been observed in various types of cancers. In this paper we first briefly outline of multiple pairwise alignment of primiRNA- 125 of three organisms and secondary structure. We then discuss in detail on binding sites of miRNA-125 with different target genes to known the binding energy using computational tool. Finally, we discuss on mechanism of miRNA-125 over-expression causes different types of leukemia due to abnormal expression of gene present on chromosome 21. Thus we have reported that one of the major causes of leukemia is abnormal expression of miRNA- 125. Ful

Computational identification and characterization of putative miRNAs in Nasonia species

MicroRNAs are important at post transcriptional regulation in eukaryotes. Nasonia genus is becoming increasingly popular model in present days due to genetic advantages it possesses over Drosophila. Nasonia species are found distributed throughout the world, expect for N. longicornis, and N. giraulti. In this study, we use the sequential method of blasting all known invertebrate miRNA genes against the Nasonia vitripennis, Nasonia longicornis, and Nasonia giraulti genomes. We identify 40, 31 and 29 putative pre-​miRNAs and mature sequences in N. vitripennis, N. giraulti and N. longicornis resp. A cross species comparison of putative miRNA sequences and their statistical characteristics reveals that there are no huge differences between the species, except for few miRNAs which are reported. We also find that the minimal folding energy index for three Nasonia species pre-​miRNA's av. is around -​0.85 ± 0.11. Further, we report that U is predominant at the 5' end of mature sequence, which being a typical characteristic of plant miRNAs. Using MiRanda, we predict nearly 471 potential sites in the N. vitripennis genome. Thus concluding our study to be the beginning of understanding the Nasonia's non coding RNAs and may play an important role in effective pest management in near future

Effect of Root Opening on Distortion of Butt-Joints in Submerged Arc Welding

The dimensional differences in steel bridge manufacturing caused by weld deformation often occur for butt joints of thin plates. The problems of distortion, residual stresses and reduced strength of structure in and around a welded joint are of major concern in the shipbuilding industry and other similar manufacturing industries. The various distortions induced by welding process and restriction of these distortions may lead to higher residual stresses. The prediction of distortions in ship panels are of great importance from the point of view of dimensional control. In view of this, it has been investigated the effect of root opening on the transverse shrinkage, longitudinal shrinkage and angular distortions of butt joints. The experimental investigations are carried out using Submerged Arc Welding with zero mm, 1 mm and 2 mm root opening for constant heat input. The transverse and longitudinal shrinkage increase but the angular distortion decreases with increase in the root opening

Computational prediction and identification of miRNAs in ssRNA viruses

MiRNAs are conserved endogenous small non-​coding RNA mols. play a very important role in posttranscriptional regulation of gene by binding to mRNA.miRNAs have been identified in plants, animals, invertebrates and even in viruses. Recent studies have proved that as like DNA viruses even cytoplasmic RNA viruses encodes miRNA by noncanonical pathway.To find the miRNAs encoded by both (+) ssRNA and (-​) ssRNA viruses, we used computational tool VMir to screen the complete genomes of selected RNA viruses. The predicted precursor miRNA hairpin structures obtained from VMir were further analyzed in miPred to identify real and pseudo miRNA. The real miRNAs analyzed in blastx program to exclude protein coding sequences and then finally identified mature miRNAs by using matureBayes.In our studies we analyzed 45 viral genomes, finally we obsd. that more miRNAs encoded by (-​) ssRNA than the (+) ssRNA

Effect of Bevel Angle in Bevel Groove Butt Joints on Shrinkages in CO2 Arc Welding Process

The in-plane distortions such as transverse shrinkages and longitudinal shrinkages induce residual stress in the welded joints which is undesirable as it reduces the strength of the welded structure. The problems of distortions in welded joints are of major concern in structures and the shipbuilding industry and in other similar manufacturing industries. The predictions of the degree of shrinkages in ship panels due to welding are of great importance from the point of view of dimensional control and it is important to analyze transverse shrinkages and longitudinal shrinkages. In this investigation, the experimental analysis of transverse shrinkages and longitudinal shrinkages bevel-groove butt welded joints in CO2 Arc Welding process by bevel angle and keeping process parameters constant. It was found that, the transverse and longitudinal shrinkages increase with increase in the bevel angle. There is a significant increase in the transverse shrinkage and small variation in longitudinal shrinkage